Does erythritol damage brain cells within hours?

Analysis Reasoning

A 2025 study found erythritol, at levels in one serving of a sweetened beverage, increases oxidative stress and damages human brain microvascular endothelial cells within 3 hours in vitro. The FDA approved erythritol decades ago, but this research raises concerns about brain and heart health risks.

Cited Sources

• 01
  American Physiological Society

  https://www.physiology.org/detail/news/2025/04/25/popular-sugar-substitute-may-harm-brain-and-heart-health

• 02
  PubMed

  https://pubmed.ncbi.nlm.nih.gov/40459966/

• 03
  ScienceAlert

  https://www.sciencealert.com/common-sweetener-may-damage-critical-brain-barrier-risking-stroke